Metabolic Disorders in Women with Climacteric Syndrome in Early Postmenopause

Introduction . Modern management of menopausal transition and early postmenopause views climacteric syndrome (CS) as a systemic, multiorgan pathology linked to increased cardiometabolic risk, requiring a multidisciplinary approach. The aim of this study is to determine the prevalence of metabolic syndrome (MS) and its phenotypes in women with climacteric syndrome in early postmenopause in order to optimize the algorithm for its early multidisciplinary diagnosis. Materials and methods . A cross-sectional study enrolled 133 women with CS in early postmenopause. The main group included 96 women with a waist circumference (WC) ≥80 cm; the comparison group comprised 37 women with a WC <80 cm. Assessment included medical history evaluation, the Greene Climacteric Scale, the Modified Menopausal Index (MMI), a visual analog scale (VAS) for hot flashes/hyperhidrosis, anthropometry and laboratory tests. Results . The prevalence of MS in women with climacteric syndrome and abdominal obesity was 62.5 %. The main phenotypes of metabolic syndrome were lipocentric, dyslipidemic, hypertensive, and renal. Patients in the main group exhibited a more severe course of climacteric syndrome versus the comparison group, according to the Greene scale (p < 0.001), the MMI (p < 0.001), and the hyperhidrosis VAS (p = 0.001). These data enabled the development of two models for optimizing diagnostic strategies. Conclusion . The high prevalence metabolic syndrome in women with abdominal obesity in early postmenopause highlights the comorbidity of climacteric and metabolic disorders. The developed models and algorithm optimize the early diagnosis of menopausal metabolic syndrome and ensure personalized multidisciplinary management of patients.