Jatropha Leaf Extract as an Anti-Glycation Cosmeceutical Hydrogel: A Review of the Evidence, Rationale and Formulation Prospects

The non-enzymatic reaction between reducing sugars (or the products of their reactive carbonyl breakdown) and proteins, lipids, or nucleic acids is known as glycation. AGEs, or advanced glycation end products, are produced by it. Long-lasting dermal proteins in the skin, such collagen and elastin, accumulate AGEs. Cross-linking, rigidity, yellowing, and elasticity loss result from this. Additionally, AGEs trigger the receptor for AGEs (RAGE), which increases inflammation and oxidative stress [1,2]. As a result, anti-glycation actives are becoming more and more popular as cosmetic additives. Since the reference inhibitor, aminoguanidine, has not been used in clinical settings [1], plant-derived polyphenols and flavonoids are being investigated as potential substitutes [10–12]. In traditional medicine, plants in the genus Jatropha (Euphorbiaceae) are frequently used to treat wounds, inflammation, and skin conditions. Vitexin and isovitexin, two C-substances prevent the production of AGEs [14–16]. The literature on (i) skin glycation and anti-glycation tactics, (ii) plant-based anti-glycation evidence and assay techniques, (iii) Jatropha leaf phytochemistry, antioxidant, anti-inflammatory, and wound-healing activity, (iv) current Jatropha topical gels, and (v) hydrogels as cosmeceutical carriers is compiled in this review. Glycosylflavones are one of the flavonoids present in their leaves, and an ion framework is suggested for further studies. In different plant systems, these.