Electrochemical sensing of dopamine using modified glassy carbon electrode

Dopamine (DPM), a crucial neurotransmitter in the central nervous system, regulates motor function, reward circuits, and cognition. Abnormal DPM levels are linked to neuro­logical disorders such as depression, schizophrenia and Parkinson's disease. Electro­chemical sensors allow for the fast, sensitive, selective, and economical detection of DPM. In this work, an electrochemical sensor to quantify DPM was designed using a reduced graphene oxide - transition metal oxide, rGO-Cu2O/Fe2O3, nanocomposite. The glassy carbon electrode was then modified, and its electrochemical performance was assessed using cyclic Voltammetry (CV) and differential pulse voltammetry (DPV). On the surface of the modified electrode containing the rGO-Cu2O/Fe2O3 nanocomposite, the oxidation current peak of DPM was twelve times greater than that of the electrode without modification. The findings indicated that the DPM detection limit ranged from 0.005 to 750.0 μM and 2.0 nM. With an effectiveness of 98.2 to 104.0 %, the electrochemical sensor for assessing DPM in DPM injection and urine samples also demonstrates a good recovery. Good selectivity, repeatability, and reproducibility are demonstrated by the produced sensor for DPM measurement.