"Fire Follows Its Meridian": Site-Specific Inflammatory Memory and the Tissue Microenvironment in Recurrent Inflammation
Review manuscript (v1.3.1). This record archives the manuscript and the complete submission package for "Fire Follows Its Meridian": Site-Specific Inflammatory Memory and the Tissue Microenvironment in Recurrent Inflammation. The manuscript operationalizes the Chinese clinical aphorism as site-addressed inflammatory recurrence (SAIR), proposes a five-layer framework (address, memory, residents, amplifiers, permission), treats the tissue microenvironment as the shared substrate of address and memory, and sets out ten falsifiable hypotheses (H1-H10) plus a staged research program. Public datasets analyzed: GEO GSE308379, GSE310145, GSE27887, GSE158432, GSE162054, GSE153760, and GSE250594. The archive includes the manuscript PDF, the full submission package ZIP, figures, reference verification, audit files, and portal copy. License: CC BY 4.0.
Authors
- Siwei Li (ORCID: https://orcid.org/0009-0006-1790-6265)
- Heng Bian (ORCID: https://orcid.org/0009-0007-4127-6387)
- Zhongyi Yang (ORCID: https://orcid.org/0009-0008-1856-3473)
- Jinzhe Li (ORCID: https://orcid.org/0009-0006-2487-613X)
- Juan Li
Publication Details
- Journal
- Zenodo (CERN European Organization for Nuclear Research)
- Published
- 2026-11-02
- DOI
- https://doi.org/10.5281/zenodo.23874546
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- preprint