Basic differences between p53 inhibition by shRNA, siRNA, HPV E6, p53 R175H or miR-372.
We harnessed the power of RNA-sequencing to understand differences between inhibition of the tumor suppressor p53 by different means: through depletion using small hairpin RNA, through depletion using small interfering RNA, through point mutation at position R175 of Tp53, or by expression of a p53-interfering microRNA miR-372. As proof of concept, we demonstrate here selective control of Tp53bp1 and Tp53bp2 by miR-372.
Authors
- Shahan Mamoor (ORCID: https://orcid.org/0000-0003-4150-0936)
Publication Details
- Journal
- Zenodo (CERN European Organization for Nuclear Research)
- Published
- 2026-11-02
- DOI
- https://doi.org/10.5281/zenodo.23891643
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- preprint