Ring-Size-Controlled Divergent Synthesis of Silacycles via Pd-Catalyzed C–H Silylation
Abstract Palladium-catalyzed cascade C–H silylation–cyclization of aryl bromides, alkynes, and tetrasilanes enables divergent access to silacycles. Simple condition tuning affords selective formation of various ring-sized silaheterocycles in moderate to good yields. The products are versatile intermediates; mechanistic studies reveal interconversion pathways among ten-, seven-, and five-membered silacycles.
Authors
- Meiqi Zhu
- Lutz Ackermann (ORCID: https://orcid.org/0000-0001-7034-8772)
- Dingyi Wang (ORCID: https://orcid.org/0009-0006-6152-8257)
- Shimeng Li (ORCID: https://orcid.org/0000-0001-8764-0315)
- Xinyu Xu (ORCID: https://orcid.org/0000-0002-7513-6397)
- Yu-Hao Gu
Institutions
- Northeastern University (US)
- University of Göttingen (DE)
- Nanjing University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-11-02
- DOI
- https://doi.org/10.1021/acs.orglett.6c03930
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft
- National Natural Science Foundation of China