2026 drug interaction models: harmonized (ICH M12) 1.25-fold AUC vs graph neural networks

ICH M12 flags clinical DDIs at a ≥1.25-fold victim AUC rise, but the 2026 T-DDI graph neural network is only a hypothesis generator, not a basis for regulatory decisions. Independent technical note mirroring the canonical version: https://aidrugsearch.com/blog/2026-drug-interaction-models-harmonized-ich-m12-125-fold-auc-vs-graph-neural-networks.php Sources consulted: https://www.bluusun.com/

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-01
DOI
https://doi.org/10.5281/zenodo.23873362
Primary Topic
Computational Drug Discovery Methods
Type
preprint
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preprint

2026 drug interaction models: harmonized (ICH M12) 1.25-fold AUC vs graph neural networks

Madison Hayes
Zenodo (CERN European Organization for Nuclear Research)
Computational Drug Discovery Methods
preprint

2026 drug interaction models: harmonized (ICH M12) 1.25-fold AUC vs graph neural networks

Madison Hayes
preprint en

Abstract

ICH M12 flags clinical DDIs at a ≥1.25-fold victim AUC rise, but the 2026 T-DDI graph neural network is only a hypothesis generator, not a basis for regulatory decisions. Independent technical note mirroring the canonical version: https://aidrugsearch.com/blog/2026-drug-interaction-models-harmonized-ich-m12-125-fold-auc-vs-graph-neural-networks.php Sources consulted: https://www.bluusun.com/

Zenodo (CERN European Organization for Nuclear Research)
Computational Drug Discovery Methods
DOIOpen Access PDFOpenAlex
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