Pilot Randomized Trial of Patient-Directed vs Fixed-Antibiotic Duration in Acute Pyelonephritis
ABSTRACT In this multi-center double-blind pilot randomized trial, patient-directed antibiotic duration after symptom resolution demonstrated similar sustained clinical resolution and adverse events compared to fixed-duration treatment among women with pyelonephritis. These findings support the feasibility of this strategy and justify a larger adequately powered randomized trial to evaluate efficacy and safety.
Authors
- Anne E. Zepeski (ORCID: https://orcid.org/0000-0001-6309-6554)
- William R. Mower (ORCID: https://orcid.org/0000-0003-1468-6501)
- Brett A. Faine (ORCID: https://orcid.org/0000-0002-5759-9857)
- Vance G. Fowler (ORCID: https://orcid.org/0000-0002-8048-0897)
- Frank LoVecchio (ORCID: https://orcid.org/0000-0002-2920-9073)
- Anusha Krishnadasan (ORCID: https://orcid.org/0009-0001-3503-3473)
- Nicholas M. Mohr (ORCID: https://orcid.org/0000-0003-0497-5828)
- David A. Talan (ORCID: https://orcid.org/0000-0002-7048-8086)
- Scott R. Evans (ORCID: https://orcid.org/0000-0003-3186-172X)
- Gregory J. Moran (ORCID: https://orcid.org/0009-0008-1566-1668)
- Jesus Torres
- Ruoyu Li (ORCID: https://orcid.org/0009-0001-3945-7716)
Institutions
- University of Iowa (US)
- University of California, Los Angeles (US)
- George Washington University (US)
- Los Angeles Medical Center (US)
- Duke Medical Center (US)
- Olive View-UCLA Medical Center (US)
- University of Iowa Health Care (US)
- Valleywise Health (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2026-11-02
- DOI
- https://doi.org/10.1093/ofid/ofag705
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00