Effectiveness and Safety of IV Magnesium Sulphate for Attenuation of Haemodynamic Responses to Intubation

Introduction with Objective: The purpose of this study was to evaluate the effectiveness and safety of intravenous magnesium sulphate in attenuating of heamodynamic response to laryngoscopy during endotracheal intubation in elective surgical procedures. Materials and Methods: This was a randomized clinical trial was completed in the Department of Anesthesiology and Intensive Care Medicine of Chittagong Medical College Hospital, Chittagong from February 2024 to August 2025. Forty one patients (18-65 years) belonging to American Society of Anesthesiologists (ASA) physical status I and II. Were randomized to receive 100 ml of solution which contain magnesium sulphate 30 mg/kg diluted with normal saline, 10 min before induction of anesthesia. Heamodynamic parameters including heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP), mean arterial pressure (MAP) and peripheral oxygen saturation (SPO2) were recorded pre-drug, after drug, at intubation, at intervals of 1 min till 5 min, at 10 min, at 20 min and at 30 min after intubation. Data were collected in separated case-record form and analyzed by SPSS 26.0. Results: The mean age of the patients was 36.56 ± 12.14 years, with a male predominance (53.8%). Most participants (53.8%) were classified as ASA II, and the mean BMI was 21.11 ± 1.51 kg/m². Heart rate showed a mild increase during and shortly after intubation (up to 3 minutes), followed by a gradual return toward baseline within 30 minutes, indicating partial attenuation of the haemodynamic response. Systolic, diastolic, and mean arterial pressures also exhibited transient elevations during intubation and the early post-intubation period, but remained within acceptable limits. Oxygen saturation (SpO2) remained stable throughout the 30-minute observation period with no significant changes (p > 0.05). Conclusion: Intravenous magnesium Sulphate was found to be safe and effective in attenuating the haemodynamic stress responses to laryngoscopy and endotracheal intubation. Medicine Today 2026, Vol.38 (2): 204-207