Explorative Correlation of Atopic Dermatitis Control Tool with Minimal Disease Activity Patient-reported Outcomes in Patients Treated with Upadacitinib: A Retrospective Real-world Study
Atopic dermatitisis a chronic skin disease that requires long-term monitoring, which can be assessed using Atopic Dermatitis Control Tool (ADCT). Achieving minimal disease activity is also becoming an important issue in the treatment of atopic dermatitis. We aimed to identify which minimal disease sctivity patient-reported outcomes most closely reflect ADCT-defined disease control. We conducted a multicentric, observational retrospective study in patients with moderate-to-severe atopic dermatitis treated with upadacitinib. Outcome measures were collected at different time points (Week 0, 4, 16, 32, 52). Longitudinal changes were assessed with the paired Wilcoxon signedrank test; cross-sectional ADCT-patient-reported outcomes associations were evaluated at each visit using Spearman rank correlation coefficient (ρ). A total of 212 were included. All outcomes improved significantly from Week 4 onwards (all p<0.001). An ADCT score<7 was reached by 84.6% of evaluable patients at Week 4 and 90.1% at Week 52. At each timepoint, ADCT showed the strongest correlation with POEM (ρ range: 0.64-0.64) compared to other minimal disease sctivity patient-reported outcomes. These findings indicate that, among the minimal disease sctivity patient-reported outcomes, POEM most closely reflects the patient's perception of atopic dermatitis control assessed by ADCT. Larger prospective studies are warranted to confirm these preliminary observations.
Authors
- Filomena Russo (ORCID: https://orcid.org/0000-0003-2780-7720)
- Helena Gioacchini (ORCID: https://orcid.org/0009-0004-4099-3243)
- Edoardo Mortato (ORCID: https://orcid.org/0009-0008-3763-6922)
- Niccolò Gori (ORCID: https://orcid.org/0000-0003-1987-0623)
- Laura Calabrese (ORCID: https://orcid.org/0000-0001-5238-2336)
- Federica Giuliani (ORCID: https://orcid.org/0000-0003-3570-4027)
- Tommaso Bianchelli (ORCID: https://orcid.org/0000-0003-1323-0158)
- Laura Lazzeri
- Paolo Amerio (ORCID: https://orcid.org/0000-0003-1589-9672)
- Marco Galluzzo (ORCID: https://orcid.org/0000-0002-3424-5175)
- Chiara Bocchi (ORCID: https://orcid.org/0000-0002-3162-4057)
- Viviana Piras (ORCID: https://orcid.org/0000-0001-8854-9441)
- Camilla Chello (ORCID: https://orcid.org/0000-0002-3142-1831)
- Laura Atzori (ORCID: https://orcid.org/0000-0002-8105-1402)
- Natale Schettini (ORCID: https://orcid.org/0000-0002-6693-766X)
- Marco Romanelli (ORCID: https://orcid.org/0000-0002-4127-0141)
- Giovanni Luca Scaglione (ORCID: https://orcid.org/0000-0001-5622-7843)
- Katharina Hansel (ORCID: https://orcid.org/0000-0002-6674-4278)
- Sabatino Pallotta (ORCID: https://orcid.org/0000-0003-4827-2892)
- Elettra Antonelli
- Maria Cannizzaro
- Ester Del Duca (ORCID: https://orcid.org/0000-0001-7948-8536)
- Flavia Margiotta
Institutions
- University of Siena (IT)
- Università Cattolica del Sacro Cuore (IT)
- University of Pisa (IT)
- University of Rome Tor Vergata (IT)
- Scuola Superiore Sant'Anna (IT)
- University of Cagliari (IT)
- University of Ferrara (IT)
- University of Perugia (IT)
- Agostino Gemelli University Polyclinic (IT)
- University of Chieti-Pescara (IT)
- Istituto Dermopatico dell'Immacolata (IT)
- Policlinico Tor Vergata (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto Nazionale di Riposo e Cura per Anziani (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Acta Dermato Venereologica
- Published
- 2026-11-02
- DOI
- https://doi.org/10.2340/actadv.v106.adv-2026-0815
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00