Beta secretase expression is a major transcriptional difference between ApoE variants.

We measured total transcription in cells and compared whole transcriptome based on cellular ApoE variant. We report discovery of beta secretase as a major transcriptional difference resulting from or associated with encoded ApoE variant that confers risk for development of Alzheimer's Disease.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-02
DOI
https://doi.org/10.5281/zenodo.23891207
Primary Topic
Alzheimer's disease research and treatments
Type
preprint
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preprint

Beta secretase expression is a major transcriptional difference between ApoE variants.

Shahan Mamoor
Zenodo (CERN European Organization for Nuclear Research)
Alzheimer's disease research and treatments
preprint

Beta secretase expression is a major transcriptional difference between ApoE variants.

Shahan Mamoor
preprint en

Abstract

We measured total transcription in cells and compared whole transcriptome based on cellular ApoE variant. We report discovery of beta secretase as a major transcriptional difference resulting from or associated with encoded ApoE variant that confers risk for development of Alzheimer's Disease.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Alzheimer's disease research and treatments
DOIOpen Access PDFOpenAlex
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Beta secretase expression is a major transcriptional difference between ApoE variants. — Shahan Mamoor · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS