AMPK/USP10 loop activation of ACE2 in pulmonary hypertension: extending the cardiovascular-kidney-metabolic continuum to the pulmonary circulation?
The cardiovascular-kidney-metabolic continuum includes the pulmonary circulation, with AMPK/USP10 loop activation as a central hub (white box in the middle of the figure) for ACE2 stability and prevention of endothelial dysfunction.
Authors
- Thomas A. Zelniker (ORCID: https://orcid.org/0000-0002-6444-8598)
- Irene Marthe Lang (ORCID: https://orcid.org/0000-0003-0485-2692)
Institutions
- Medical University of Vienna (AT)
Publication Details
- Journal
- European Heart Journal
- Published
- 2026-11-02
- DOI
- https://doi.org/10.1093/eurheartj/ehag762
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00