Lefty1 interacts with the imprinting system and activates expression of stem cell factors mobilized in transformation and cancer.

We present here molecular evidence demonstrating transcriptional program similarity during germ layer commitment decisions and transcriptional activity in the cancer cell. The program overlap was defined by Lefty1 activation and associated with specific mobilization of stem cell factors.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-02
DOI
https://doi.org/10.5281/zenodo.23889378
Primary Topic
Developmental Biology and Gene Regulation
Type
preprint
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preprint

Lefty1 interacts with the imprinting system and activates expression of stem cell factors mobilized in transformation and cancer.

Shahan Mamoor
1 links
Zenodo (CERN European Organization for Nuclear Research)
Developmental Biology and Gene Regulation
preprint

Lefty1 interacts with the imprinting system and activates expression of stem cell factors mobilized in transformation and cancer.

Shahan Mamoor
preprint en

Abstract

We present here molecular evidence demonstrating transcriptional program similarity during germ layer commitment decisions and transcriptional activity in the cancer cell. The program overlap was defined by Lefty1 activation and associated with specific mobilization of stem cell factors.

Zenodo (CERN European Organization for Nuclear Research)
Developmental Biology and Gene Regulation
DOIOpen Access PDFOpenAlex
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Lefty1 interacts with the imprinting system and activates expression of stem cell factors mobilized in transformation and cancer. — Shahan Mamoor · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS