PHARMACOLOGICAL EVALUATION OF "ANTI-DEVELOPMENT AND IN VITRO EVALUATION OF SELEGILINE TRANSDERMAL PATCHES

The present study was aimed at the formulation and evaluation of Selegiline hydrochloride transdermal patches to provide sustained drug release and improve patient compliance by overcoming the limitations associated with conventional oral therapy. It was freely soluble in methanol and ethanol, soluble in chloroform, and slightly soluble in water and phosphate buffer (pH 7.4). The maximum absorption wavelength (λmax) was found to be 247 nm, and the calibration curve exhibited excellent linearity with an R² value of 0.999. FTIR studies confirmed the compatibility of Selegiline hydrochloride with the selected polymers, indicating the absence of significant drug–excipient interactions.Transdermal patches were prepared by the solvent casting method using HPMC and Eudragit RL100 as film-forming polymers, PEG 400 as a plasticizer, and DMSO as a permeation enhancer. The prepared patches were evaluated for physicochemical parameters, including physical appearance, weight variation, thickness, folding endurance, surface pH, moisture loss, moisture absorption, in vitro drug release, and stability.All formulations showed satisfactory physicochemical characteristics with uniform appearance, acceptable thickness, good flexibility, and surface pH values within the normal skin pH range. Among the prepared formulations, F4, containing 50 mg of Eudragit RL100, demonstrated the best overall performance, exhibiting the highest folding endurance and a maximum cumulative drug release of 98.10% over 12 hours. Accelerated stability studies of the optimized formulation carried out according to ICH guidelines showed no significant changes in physical appearance, with only a slight reduction in cumulative drug release (97.82%) after three months, indicating good stability.The findings of this study suggest that the optimized Selegiline hydrochloride transdermal patch is a promising sustained-release drug delivery system with satisfactory physicochemical properties, drug release characteristics, and stability. Keywords: Selegiline hydrochloride, Transdermal patch, Solvent casting, Sustained drug release, FTIR, Stability studies.