Anterior Cervical Discectomy and Fusion Versus Cervical Disc Arthroplasty for Cervical Degenerative Disc Disease: Alarming Rates of Bias

Study DesignCross-Sectional.ObjectivesWhether cervical disc arthroplasty (CDA) or anterior cervical discectomy and fusion (ACDF) yields better outcomes in cervical degenerative disc disease remains unsettled, and clinicians turn to evidence syntheses for guidance. These syntheses, however, may contain spin, a reporting bias that presents an intervention as more effective or safer than the data support. This study sought to characterize how often spin appears in reviews comparing ACDF and CDA, which forms it takes, and whether methodological quality, journal impact factor, or citation rate predicts spin outcomes.MethodsPubMed, Web of Science, and Embase were searched for systematic reviews and meta-analyses directly comparing ACDF and CDA. Each article was assessed for spin using the Yavchitz classification system and for methodological quality (AMSTAR-2). Logistic and Poisson regression assessed whether study AMSTAR-2 rating, journal impact factor, and yearly citations predicted spin outcomes.Results77 articles were included. Spin was identified in 49 (63.6%); all spin-positive reviews favored CDA. The most frequent types were claiming benefit despite high risk of bias (39.0%), overemphasis on efficacy (26.0%), and selective safety reporting (15.6%). AMSTAR-2 ratings were poor: 83.1% were critically low, 15.6% low, and 1.3% high. Lower AMSTAR-2 rating independently predicted spin (OR 0.182, 95% CI 0.048-0.689, p = 0.012); impact factor and citations did not.ConclusionsSpin is prevalent in reviews comparing CDA with ACDF and uniformly favors CDA. Greater methodological rigor and balanced reporting are needed for evidence syntheses to reliably inform clinical decisions.

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Publication Details

Journal
Global Spine Journal
Published
2026-11-02
DOI
https://doi.org/10.1177/21925682261504746
Primary Topic
Meta-analysis and systematic reviews
Type
article
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article

Anterior Cervical Discectomy and Fusion Versus Cervical Disc Arthroplasty for Cervical Degenerative Disc Disease: Alarming Rates of Bias

Thomas W. Mason, Ram Kiran Alluri, Raymond J. Hah, Henry Avetisian et al.
2 links
Global Spine Journal
Meta-analysis and systematic reviews
article

Anterior Cervical Discectomy and Fusion Versus Cervical Disc Arthroplasty for Cervical Degenerative Disc Disease: Alarming Rates of Bias

Thomas W. Mason, Ram Kiran Alluri, Raymond J. Hah, Henry Avetisian, Joshua Davood, Daniel Rusu, Apurva Prasad, Marco Napolitano, William J. Karakash, Joshua Khorsandi, Aidan R. Lindgren, Joseph Borna, Nicole Kahen, Jeffrey C. Wang, Joseph Noorvash
article en

Abstract

Study DesignCross-Sectional.ObjectivesWhether cervical disc arthroplasty (CDA) or anterior cervical discectomy and fusion (ACDF) yields better outcomes in cervical degenerative disc disease remains unsettled, and clinicians turn to evidence syntheses for guidance. These syntheses, however, may contain spin, a reporting bias that presents an intervention as more effective or safer than the data support. This study sought to characterize how often spin appears in reviews comparing ACDF and CDA, which forms it takes, and whether methodological quality, journal impact factor, or citation rate predicts spin outcomes.MethodsPubMed, Web of Science, and Embase were searched for systematic reviews and meta-analyses directly comparing ACDF and CDA. Each article was assessed for spin using the Yavchitz classification system and for methodological quality (AMSTAR-2). Logistic and Poisson regression assessed whether study AMSTAR-2 rating, journal impact factor, and yearly citations predicted spin outcomes.Results77 articles were included. Spin was identified in 49 (63.6%); all spin-positive reviews favored CDA. The most frequent types were claiming benefit despite high risk of bias (39.0%), overemphasis on efficacy (26.0%), and selective safety reporting (15.6%). AMSTAR-2 ratings were poor: 83.1% were critically low, 15.6% low, and 1.3% high. Lower AMSTAR-2 rating independently predicted spin (OR 0.182, 95% CI 0.048-0.689, p = 0.012); impact factor and citations did not.ConclusionsSpin is prevalent in reviews comparing CDA with ACDF and uniformly favors CDA. Greater methodological rigor and balanced reporting are needed for evidence syntheses to reliably inform clinical decisions.

Global Spine Journal
University of Southern California (US), University of Nevada, Las Vegas (US)
Good health and well-being
Openalex Percentile: Top 13%
Meta-analysis and systematic reviews
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