APC responds to changes in size of the cell (cellular growth).

We used cellular models of plasticity in cell shape (YAP depletion or E-cadherin expression) and tumor suppressor deficiency (APC mutation) to demonstrate a relationship between changes in cellular growth that affect cell size and shape and the APC tumor suppression pathway. APC mutation was associated with activation of the ARC gene.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-02
DOI
https://doi.org/10.5281/zenodo.23890362
Primary Topic
Hippo pathway signaling and YAP/TAZ
Type
preprint
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preprint

APC responds to changes in size of the cell (cellular growth).

Shahan Mamoor
Zenodo (CERN European Organization for Nuclear Research)
Hippo pathway signaling and YAP/TAZ
preprint

APC responds to changes in size of the cell (cellular growth).

Shahan Mamoor
preprint en

Abstract

We used cellular models of plasticity in cell shape (YAP depletion or E-cadherin expression) and tumor suppressor deficiency (APC mutation) to demonstrate a relationship between changes in cellular growth that affect cell size and shape and the APC tumor suppression pathway. APC mutation was associated with activation of the ARC gene.

Zenodo (CERN European Organization for Nuclear Research)
Hippo pathway signaling and YAP/TAZ
DOIOpen Access PDFOpenAlex
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APC responds to changes in size of the cell (cellular growth). — Shahan Mamoor · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS