Night-Shift Work and Incident Cardiovascular Disease in Adults With Depression Across Baseline Risk Profiles: A UK Biobank Study

OBJECTIVE: To evaluate whether night-shift work is associated with incident cardiovascular disease (CVD) across baseline CVD risk profiles among adults with depression. METHODS: In this prospective cohort study, we analyzed 52,565 UK Biobank participants with baseline depression. Night-shift work was identified from baseline and employment-history data. Cox models estimated adjusted hazard ratios (aHRs) across low-, intermediate-, and high-risk profiles. RESULTS: Of 52,565 participants, 25,360 had a history of night-shift work. Compared with participants without night-shift work, those with night-shift work had higher CVD risk in the low-risk (aHR 1.33, 95% CI 1.20-1.49), intermediate-risk (1.25, 1.17-1.33), and high-risk (1.36, 1.23-1.51) groups (interaction P=0.016). CONCLUSIONS: Among adults with depression, night-shift work was associated with higher incident CVD risk across baseline risk profiles.