Hydroxychloroquine‐Associated Renal Phospholipidosis: A Forgotten Complication of a Common Drug
ABSTRACT Hydroxychloroquine (HCQ) treatment in systemic lupus erythematosus can induce drug‐induced phospholipidosis mimicking Fabry disease. A 32‐year‐old woman with lupus nephritis developed podocyte “zebra bodies” on electron microscopy. Normal lyso‐Gb3 excluded Fabry disease, confirming HCQ toxicity. Discontinuation and immunosuppression yielded stable renal function and improved proteinuria.
Authors
- Chun‐Hsin Wu (ORCID: https://orcid.org/0000-0002-1081-7458)
- Yu‐Chien Tsao (ORCID: https://orcid.org/0000-0001-6692-7608)
Institutions
- National Cheng Kung University Hospital (TW)
- National Cheng Kung University (TW)
Publication Details
- Journal
- Clinical Case Reports
- Published
- 2026-11-01
- DOI
- https://doi.org/10.1002/ccr3.73874
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00