DEVELOPMENT AND INVITRO CHARACTERISATION OF PANTAPROZOLE SODIUM TABLETS BY USING NATURAL DISINTEGRANTS

The present study was aimed at the formulation and evaluation of Pantoprazole sodium tablets using natural polymers such as Tragacanth and Guar gum by the direct compression method. Pantoprazole sodium is a proton pump inhibitor widely used in the treatment of gastric and duodenal ulcers, gastroesophageal reflux disease, and other acid-related disorders. The objective of the study was to develop a stable tablet formulation with satisfactory physicochemical characteristics and drug release profile.Preformulation studies including organoleptic evaluation, melting point determination, solubility studies, calibration curve preparation, and FTIR compatibility studies were carried out. Pantoprazole sodium was found to be compatible with the selected excipients, as confirmed by FTIR analysis. The powder blends were evaluated for bulk density, tapped density, compressibility index, Hausner ratio, and angle of repose, and all formulations exhibited satisfactory flow properties suitable for direct compression.Four formulations (F1–F4) were prepared using varying concentrations of Tragacanth and Guar gum. The prepared tablets were evaluated for weight variation, thickness, hardness, friability, drug content, disintegration time, and in vitro drug release. All formulations complied with pharmacopoeial specifications. The cumulative drug release after 8 hours ranged from 93.22% to 98.12%. Among the formulations, F4 showed the highest drug release of 98.12% and was selected as the optimized formulation.The optimized formulation was subjected to accelerated stability studies at different storage conditions for a period of 90 days. The formulation remained stable without any significant changes in physical appearance or drug release profile.The study concluded that Pantoprazole sodium tablets prepared using Tragacanth and Guar gum exhibited satisfactory physicochemical properties, good drug release characteristics, and acceptable stability. The optimized formulation may serve as a promising oral dosage form for effective drug delivery. Keywords: Pantoprazole Sodium, Direct Compression, , FTIR, Dissolution Study, Stability Studies.