Stoichiometric Binding of Cyclophilin‐A to The HIV‐1 Capsid Modulates Its Mechanoelastic Properties (Small 61/2026)

Nanomechanics The HIV-1 capsid is a protein nanocapsule that must remain stable enough to protect the viral genome while deformable enough to traverse the nuclear pore. In Research Article e75453, Juan R. Perilla and co-workers utilize atomic force microscopy simulations to elucidate how Cyclophilin A binding modulates capsid brittleness, revealing a stoichiometric balance between host-factor surface coverage and the mechanoelastic properties required for nuclear entry.