Molybdenum-Catalyzed Reductive C–N Coupling/Cyclization Cascade for the De Novo Construction of N -Substituted Oxindoles
A simple and practical Mo-catalyzed method has been developed for the de novo and efficient synthesis of versatile N-substituted oxindoles via a reductive C-N coupling/cyclization cascade. This protocol features inexpensive starting materials, broad functional group tolerance, and is applicable to the late-stage modification or synthesis of biorelevant targets.
Authors
- Xiaobo Xu (ORCID: https://orcid.org/0000-0003-0380-8702)
- Xie Xiu-zhe
- Zhong‐Yan Cao (ORCID: https://orcid.org/0000-0002-6858-5629)
- Zi Yang (ORCID: https://orcid.org/0000-0002-8377-118X)
- Weijia Wang (ORCID: https://orcid.org/0000-0003-0602-8162)
- Shengnan Jin (ORCID: https://orcid.org/0000-0003-1628-3378)
- Bei Ge
- Chunhong Zhang
- He-Han Feng
Institutions
- Changsha Medical University (CN)
- Nanjing Forestry University (CN)
- Henan University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Huanghuai University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-11-02
- DOI
- https://doi.org/10.1021/acs.joc.6c02319
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Postdoctoral Science Foundation
- Natural Science Foundation of Henan Province
- Key Scientific Research Project of Colleges and Universities in Henan Province
- Science and Technology Innovation Talents in Universities of Henan Province