A Review on Curcumin Loaded Nanoemulgel for Wound Healing Activity

Wound healing is a natural process in which the body repairs damaged tissues through several stages, including inflammation, new tissue formation, and tissue remodeling. Curcumin, a natural chemical compound derived from turmeric (Curcuma longa), has attracted interest because of its antioxidant, anti-inflammatory, antimicrobial, and wound-repairing activities. It may help in wound healing by controlling inflammation, reducing oxidative damage, supporting collagen formation, promoting the development of new blood vessels, and improving wound closure. Despite these beneficial effects, the use of curcumin is limited by its poor solubility in water, low bioavailability, and lack of stability under certain conditions. To address these challenges, researchers are exploring advanced drug delivery systems, such as nanoparticles, nanoemulgels, and hydrogels, to improve curcumin's stability and effectiveness. This review focuses on the chemical characteristics of curcumin, its role and mechanisms in wound healing, its benefits and limitations, and the development of improved formulations. It also discusses future research opportunities and the need for further clinical studies to confirm its safety and therapeutic benefits in humans. Curcumin may be a useful candidate for wound management; however, more evidence is needed before its full clinical potential can be established..