FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF MONTELUKAST SODIUM FOR ASTHMA

Buccal tablet of oral formulations of these drugs have been developed to improve their acceptability to patients and thus improve compliance. The focus of present investigation was to improve solubility, bioavailability and to achieved rapid onset action. Buccal tablets of Montelukast Sodium were prepared by direct compression technique. Four Formulations were formulated using Ethyl cellulose and HPMC as polymers on Swelling index, Disintegration time. In addition, the prepared tablets were also evaluated for weight variation, thickness, moisture absorption, friability, content uniformity, wetting time and drug release studies. Formulation reveals fast dissolution and disintegration rate of optimized Montelukast Sodium buccal tablets. Keywords: Montelukast Sodium, Direct compression technique, FTIR studies, Synthetic polymer, Drug release studies.