Complement deposition in the bone marrow of patients with myelodysplastic neoplasms
In this study, we aimed to characterize IgG, IgM and complement fractions deposition in the BM of low-risk myelodysplastic syndrome (LR-MDS) 1 patients by immunohistochemistry and flow cytometry to assess the role of complement and humoral immunity on ineffective erythropoiesis and its clinical implications. Furthermore, we investigated the expression of complement related genes in MDS versus healthy donors by single-cell RNA sequencing, with the goal of defining whether complement activation represents a recurrent and targetable feature of LR-MDS. The study was approved by the Ethics Committees of Human Experimentation, and patients gave informed consent in accordance with the Declaration of Helsinki.
Authors
- Francesca Lazzaroni (ORCID: https://orcid.org/0000-0001-5767-7846)
- Anna Zaninoni (ORCID: https://orcid.org/0000-0002-8614-3904)
- Francesco Passamonti (ORCID: https://orcid.org/0000-0001-8068-5289)
- Marzia Barbieri (ORCID: https://orcid.org/0000-0002-9027-1888)
- Giorgio Alberto Croci (ORCID: https://orcid.org/0000-0001-5979-7841)
- Wilma Barcellini (ORCID: https://orcid.org/0000-0003-1428-9944)
- Niccolò Bolli (ORCID: https://orcid.org/0000-0002-1018-5139)
- Giacinto Luca Pedone (ORCID: https://orcid.org/0009-0000-7727-2766)
- Federico Colombo (ORCID: https://orcid.org/0000-0003-4480-3481)
- Cecilia Anna Fidanza (ORCID: https://orcid.org/0000-0002-9988-6408)
- Bruno Fattizzo (ORCID: https://orcid.org/0000-0003-0857-8379)
- Matteo Da Vià (ORCID: https://orcid.org/0000-0002-5396-6584)
- Alessandra Cattaneo (ORCID: https://orcid.org/0000-0002-4500-6540)
- Alessandro Bosi (ORCID: https://orcid.org/0000-0002-7686-2171)
- Claudia Leoni
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
Publication Details
- Journal
- Signal Transduction and Targeted Therapy
- Published
- 2026-11-02
- DOI
- https://doi.org/10.1038/s41392-026-03052-1
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pfizer
- Ministero della Salute
- Associazione Italiana per la Ricerca sul Cancro