Efek Ekstrak Bonggol Nanas Madu (Ananas comosus L. Merr) terhadap Penurunan Jumlah Sel Plasma pada Gingivitis Tikus Wistar

Gingivitis is an inflammatory condition of the gingival tissue characterized by the presence of inflammatory cells, including plasma cells that play a role in the immune response. The pineapple core extract (Ananas comosus L. Merr) contains bioactive compounds such as bromelain and flavonoids that have potential as anti-inflammatory agents. The aim of this study was to evaluate the effect of pineapple core extract (Ananas comosus L. Merr) at concentrations of 12.5% and 25% on the number of plasma cells in the gingival tissue of Wistar rats with histologically confirmed gingivitis, and to determine the concentration that produced the greatest reduction in the number of plasma cells. A laboratory experimental study using a post-test only control group design was conducted on Wistar rats, which were divided into control and treatment groups administered pineapple core extract at concentrations of 12.5% and 25%. Gingivitis was induced using ligation, followed by the preparation of histological sections stained with hematoxylin-eosin to observe plasma cell counts using a light microscope. Data were analyzed using Tukey’s HSD post hoc test. The treatment group showed a lower number of plasma cells compared to the control group with a statistically significant difference (p < 0.05), where the 25% concentration showed a greater reduction compared to 12.5%. The pineapple core extract demonstrates an effect in reducing the number of plasma cells in gingivitis in Wistar rats.