Case Report: Restitution of Retinal Pigment Epithelium Tear in Polypoidal Choroidal Vasculopathy

Abstract Background Retinal pigment epithelial tear is a severe complication of pigment epithelial detachment, particularly prevalent in age‑related macular degeneration, and can result in significant and persistent visual functional impairment. Under certain pathological conditions, the torn edges of the Retinal pigment epithelial may also undergo reapproximation and reattachment. Case Presentation: A 56-year-old male patient was clinically diagnosed with wet Age-related Macular Degeneration complicated by Retinal pigment epithelial tear in the right eye. The patient received intravitreal ranibizumab injections under a 3 + PRN regimen. After three consecutive injections, the pre-existing pigment epithelial detachment completely resolved, and the RPE tear margins were repositioned with good apposition. Conclusions When pigment epithelial detachment is predominantly serous in nature and sub-RPE fibrotic traction is not conspicuous, the torn margins of the RPE may have the potential for reapproximation and reattachment.

Authors

Publication Details

Journal
Research Square
Published
2026-11-01
DOI
https://doi.org/10.21203/rs.3.rs-11238109/v1
Primary Topic
Retinal Diseases and Treatments
Type
preprint
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
preprint

Case Report: Restitution of Retinal Pigment Epithelium Tear in Polypoidal Choroidal Vasculopathy

Xi Lv, Xintong Yu, Jianmin Wang
Research Square
Retinal Diseases and Treatments
preprint

Case Report: Restitution of Retinal Pigment Epithelium Tear in Polypoidal Choroidal Vasculopathy

Xi Lv, Xintong Yu, Jianmin Wang
preprint en

Abstract

Abstract Background Retinal pigment epithelial tear is a severe complication of pigment epithelial detachment, particularly prevalent in age‑related macular degeneration, and can result in significant and persistent visual functional impairment. Under certain pathological conditions, the torn edges of the Retinal pigment epithelial may also undergo reapproximation and reattachment. Case Presentation: A 56-year-old male patient was clinically diagnosed with wet Age-related Macular Degeneration complicated by Retinal pigment epithelial tear in the right eye. The patient received intravitreal ranibizumab injections under a 3 + PRN regimen. After three consecutive injections, the pre-existing pigment epithelial detachment completely resolved, and the RPE tear margins were repositioned with good apposition. Conclusions When pigment epithelial detachment is predominantly serous in nature and sub-RPE fibrotic traction is not conspicuous, the torn margins of the RPE may have the potential for reapproximation and reattachment.

Research Square
Good health and well-being
Retinal Diseases and Treatments
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Laika access coming soon