Universal versus Targeted Q-CHAT-10 Autism Screening: Economic Evaluation in Chile and England | Reproducibility Repository

This repository provides the R code, model specifications, parameter documentation, and computational materials supporting the study "Universal versus Targeted Q-CHAT-10 Autism Screening: Economic Evaluation in Chile and England." The study uses prevalence-anchored decision-analytic cost-consequence models to compare universal and developmentally targeted autism screening in hypothetical cohorts of 100,000 children in Chile and England. The repository documents deterministic analyses, probabilistic sensitivity analyses, structural uncertainty assessments, diagnostic-capacity scenarios, economic outcomes, and model-validation procedures. It also includes methodological documentation and supplementary sensitivity analyses developed during peer review. The analyses use published aggregate evidence, administrative statistics, and documented modeling assumptions. No individual-level participant data are included. The repository is intended to facilitate methodological transparency, independent evaluation, and computational reproducibility of the reported findings.