Sustaining and Exploiting the RISK-HUNT3R Innovation Ecosystem for Next Generation Safety Assessment

The long-term impact of RISK-HUNT3R depends not only on the scientific results generated during the project, but on whether its methods, data, digital resources and knowledge continue to be used, developed and translated into research, regulatory and innovation practice. WP10 therefore addresses sustainability and exploitation as a transition from project outputs to a continuing ecosystem for Next Generation Risk Assessment (NGRA). RISK-HUNT3R has generated a portfolio of complementary scientific and digital innovations spanning NAMs, computational methods, data and knowledge infrastructure, evidence workflows and decision-support approaches. Innovation Radar activities have helped identify and characterise exploitable results, including the RISK-HUNT3R Knowledge Infrastructure, ToxTemp, ASPA-based safety assessment resources and the SaferWorldbyDesign platform. Sustainability involves maintaining access to these resources while enabling their continued scientific development, integration and application. Several emerging activities demonstrate this pathway beyond the original project. FAIR principles developed for experimental data are being extended towards computational models through OpenModel; ASPA evidence workflows provide a basis for increasingly structured and AI-assisted evidence assessment; knowledge graph approaches support mechanistic interpretation and explainable evidence integration; and RISK-HUNT3R concepts are contributing to wider OpenTox framework development. The same foundations are also being extended from NGRA towards Safe and Sustainable by Design (SSbD), where safety evidence must be integrated with functionality, environmental sustainability, life-cycle and socio-economic considerations. SaferWorldbyDesign provides one route for translating these developments into practical applications supporting safer and more sustainable innovative product development. Publications, open resources, training, follow-on research and innovation projects, community engagement and commercial development provide complementary pathways for continued adoption. The RISK-HUNT3R legacy can therefore be understood not as a static collection of project outputs, but as a foundation for a continuing evidence ecosystem connecting scientific knowledge, digital infrastructure, human expertise and AI-assisted workflows to future safety and sustainability decisions.