ANALISIS KORELASI KADAR HIGH DENSITY LIPOPROTEIN (HDL) DAN LOW DENSITY LIPOPROTEIN (LDL) TERHADAP Hs-CRP PADA PASIEN PROLANIS HIPERTENSI

Hypertension is a major risk factor for cardiovascular disease and is associated with lipid metabolism disorders and systemic inflammation. Therefore, analyzing the relationship between lipid profiles and inflammatory markers is important for supporting cardiovascular risk monitoring in patients enrolled in the Chronic Disease Management Program (Prolanis) with hypertension. This study aimed to analyze the correlation of High-Density Lipoprotein (HDL) and Low-Density Lipoprotein (LDL) levels with high-sensitivity C-reactive protein (Hs-CRP) levels. An observational analytical study with a cross-sectional design was conducted involving 30 hypertensive patients enrolled in Prolanis. HDL and LDL levels were measured using the Homogeneous Enzymatic Colorimetric method, while Hs-CRP levels were measured using the Fluorescence Immunoassay (FIA) method. Data were analyzed using Spearman’s correlation test with a significance level of 0.05. The results showed mean HDL, LDL, and Hs-CRP levels of 35.9 mg/dL, 109.9 mg/dL, and 2.6 mg/L, respectively. No significant correlation was found between HDL and Hs-CRP (r = 0.126; p = 0.507) or between LDL and Hs-CRP (r = 0.055; p = 0.771). In conclusion, HDL and LDL levels were not significantly correlated with Hs-CRP levels in the study participants. These findings suggest that the relationship between lipid profiles and inflammation warrants further investigation, considering other clinical factors. ABSTRAK Hipertensi merupakan faktor risiko utama penyakit kardiovaskular yang berkaitan dengan gangguan metabolisme lipid dan inflamasi sistemik. Oleh karena itu, analisis hubungan profil lipid dengan penanda inflamasi penting untuk mendukung pemantauan risiko kardiovaskular pada pasien Program Pengelolaan Penyakit Kronis (Prolanis) hipertensi. Penelitian ini bertujuan menganalisis korelasi kadar High-Density Lipoprotein (HDL) dan Low-Density Lipoprotein (LDL) dengan kadar high-sensitivity C-reactive protein (Hs-CRP). Penelitian ini menggunakan desain analitik observasional dengan pendekatan cross-sectional pada 30 pasien Prolanis hipertensi. Pemeriksaan HDL dan LDL menggunakan metode Homogeneous Enzymatic Colorimetric, sedangkan Hs-CRP diperiksa menggunakan metode Fluorescence Immunoassay (FIA). Data dianalisis menggunakan uji korelasi Spearman dengan tingkat signifikansi 0,05. Hasil penelitian menunjukkan rerata kadar HDL sebesar 35,9 mg/dL, LDL sebesar 109,9 mg/dL, dan Hs-CRP sebesar 2,6 mg/L. Tidak ditemukan korelasi yang signifikan antara HDL dan Hs-CRP (r = 0,126; p = 0,507) maupun antara LDL dan Hs-CRP (r = 0,055; p = 0,771). Dengan demikian, kadar HDL dan LDL tidak berhubungan secara signifikan dengan kadar Hs-CRP pada responden penelitian. Temuan ini menunjukkan bahwa hubungan profil lipid dan inflamasi perlu dikaji dengan mempertimbangkan faktor klinis lainnya.