Factors Associated with the Presence of Colorectal Polyps Measuring ≥ 10 Mm: A Single-Center Study

Background/Introduction: Colorectal polyp size is a major determinant of the risk of progression to colorectal cancer. Polyps measuring 10 mm or larger are considered higher-risk lesions and require tailored endoscopic management. The objective of this study was to identify factors associated with the presence of colorectal polyps measuring ≥ 10 mm. Patients and Methods: This was a single-center cross-sectional study including 264 patients who underwent colonoscopy with discovery of at least one colorectal polyp. Primary analysis focused on 247 patients for whom polyp size was recorded. The primary outcome was the presence of at least one polyp measuring ≥ 10 mm. Demographic, clinical, and endoscopic factors were compared using Chi-square test, Mann-Whitney U test, and multivariate logistic regression. Results: Among 247 patients analyzed, 100 patients (40.5%) presented with at least one polyp measuring ≥ 10 mm. The median size of the largest polyp was 7 mm (range: 2–50 mm). A personal history of polyps was significantly associated with the presence of a polyp ≥ 10 mm in univariate analysis (44.4% vs. 27.2%; p = 0.011; unadjusted OR = 2.10, 95% CI: 1.22–3.60). In multivariate analysis, the number of polyps was the only factor independently associated with the presence of a large polyp (adjusted OR = 1.89; 95% CI: 1.11–3.21; p = 0.018). Age, sex, hematochezia, and personal history of polyps were not significantly associated after adjustment. Conclusion: In this cohort, approximately four out of ten patients presented with at least one colorectal polyp measuring ≥ 10 mm. A higher polyp count was independently associated with the presence of large polyps. These findings emphasize the necessity of complete colonic evaluation and tailored post-polypectomy surveillance.