Improved Programs for Injury Categorization Using ICD-10

Background: Among the many efforts to convert International Classification of Diseases (ICD) codes into useful categories and scores for injury research has been the "ICD Programs for Injury Categorization” (ICDPIC). Methods: Data from the American College of Surgeons Trauma Quality Program (TQP) and US National Inpatient Sample (NIS) were used to develop Version 2 of ICDPIC for the R language (ICDPIC-R2). Programming efficiency was increased and new injury categorizations were added. Effect estimates for each ICD-10 Clinical Modification (ICD-10-CM) code were derived using logistic ridge regression with hospital mortality as the outcome. These estimates were converted to Abbreviated Injury Scale (AIS), Maximum AIS (MAIS), Injury Severity Score (ISS), and New Injury Severity Score (NISS). ICD-based Injury Severity Score (ICISS) was also calculated using TQP, NIS, and previously published data from an International Collaborative Effort for Injury Statistics (ICE-ICISS). Mortality predictions from ICDPIC-R2 were compared to those from ICDPIC Version 1 for R (ICDPIC-R1). Predictions derived from TQP data were partially validated using NIS data, and vice versa. Results: Among 1,178,107 patient records in TQP or NIS, there were 8,427 distinct ICD-10-CM anatomic injury diagnosis codes. Regression results or predictions of mortality derived from AIS in ICDPIC-R2 were satisfactory measures of severity (evaluated using area under a Receiver Operating Characteristic curve or mean square error) and improved slightly on predictions obtained with ICDPIC-R1. ICISS methods (new in ICDPIC-R2) were also quite accurate, including ICE-ICISS. Predictions derived from TQP data performed well with NIS data, and vice versa. Runtimes were much faster with ICDPIC-R2. Effect estimates from ICD-10-CM codes and ICE-ICISS were applied to an additional 12,124 possible ICD-10 codes, including all those published by the World Health Organization. Conclusion: ICDPIC remains reasonably accurate for categorizing injured patients, especially when only ICD codes are available. ICDPIC-R2 adds features and may extend applicability, especially for international data. Keywords: wounds and injuries, abbreviated injury scale, injury severity score, International Classification of Diseases, ICISS, ICDPIC, ICDPICR