Ints6 is activated by KRas G12V.

Transcriptional dynamics influenced or controlled by KRas are of profound importance to understanding the progression to the malignant state. We demonstrate here through measurement of total transcription by RNA-sequencing in human cells expressing either wild-type KRas or oncogenic mutant KRas G12V activation of the integrator gene product Ints6 in human cells expressing KRas G12V.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-10-31
DOI
https://doi.org/10.5281/zenodo.23837513
Primary Topic
Protein Kinase Regulation and GTPase Signaling
Type
preprint
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preprint

Ints6 is activated by KRas G12V.

Shahan Mamoor
Zenodo (CERN European Organization for Nuclear Research)
Protein Kinase Regulation and GTPase Signaling
preprint

Ints6 is activated by KRas G12V.

Shahan Mamoor
preprint en

Abstract

Transcriptional dynamics influenced or controlled by KRas are of profound importance to understanding the progression to the malignant state. We demonstrate here through measurement of total transcription by RNA-sequencing in human cells expressing either wild-type KRas or oncogenic mutant KRas G12V activation of the integrator gene product Ints6 in human cells expressing KRas G12V.

Zenodo (CERN European Organization for Nuclear Research)
Protein Kinase Regulation and GTPase Signaling
DOIOpen Access PDFOpenAlex
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Ints6 is activated by KRas G12V. — Shahan Mamoor · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS