CACA guidelines for holistic integrative management of PET imaging

Abstract The CACA guidelines standardize the clinical application of positron emission tomography (PET) for holistic and integrative tumor management. It systematically introduces the technical evolution of PET/CT and PET/MR, imaging principles, standardized procedures, and clinical indications. The guidelines specify the use of 18 F-FDG as the fundamental metabolic tracer and the rational application of targeted probes, including 68 Ga-PSMA, 68 Ga-FAPI, somatostatin receptor, and estrogen receptor tracers, along with quantitative parameters such as SUV, MTV, and TLG. It unifies patient preparation, radiopharmaceutical injection, scanning protocols, and report writing to ensure a consistent quality. PET is indicated for pretreatment staging, efficacy evaluation, recurrence detection, prognostic assessment, and radiotherapy target delineation in patients with major cancers. However, its limitations include false negatives in low-metabolism tumors, tumor heterogeneity, and resolution constraints. Multimodal imaging, combined tracers, and advanced equipment are recommended to improve the accuracy. This guideline promotes standardized and precise PET applications in the whole-course management of tumors in China.

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Publication Details

Journal
Holistic Integrative Oncology
Published
2026-10-30
DOI
https://doi.org/10.1007/s44178-026-00305-5
Primary Topic
Medical Imaging Techniques and Applications
Type
article
Field-Weighted Citation Impact
0.00
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article

CACA guidelines for holistic integrative management of PET imaging

徐文贵, 李林法, 杨国仁, 邱大胜 et al.
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Holistic Integrative Oncology
Medical Imaging Techniques and Applications
article

CACA guidelines for holistic integrative management of PET imaging

徐文贵, 李林法, 杨国仁, 邱大胜, Shaoli Song, Yingjian Zhang, Jing Wang, Xu Zhang, Mo Yi, Liang Ying, Xiao Guoyou, Dai Dong, Fu Wei, Fan Wei, Xiaoliang Chen, Zhongyi Yang, Yali Cui, Hui Yang, Zhijun Chen, Cheng Jingyi, Yu Lijuan, Yang Jianwei, Hu Yingying, Zhang Wanchun, Zhao Xinming, Yu Jiangyuan, Yang Aimin, Wang Xuejuan, Li Nan, Zhang Zhaoqi, Cheng Zhuzhong, Ye Hui, Zhang Jingmian, Guan Yihui, Zheng Rong
article en

Abstract

Abstract The CACA guidelines standardize the clinical application of positron emission tomography (PET) for holistic and integrative tumor management. It systematically introduces the technical evolution of PET/CT and PET/MR, imaging principles, standardized procedures, and clinical indications. The guidelines specify the use of 18 F-FDG as the fundamental metabolic tracer and the rational application of targeted probes, including 68 Ga-PSMA, 68 Ga-FAPI, somatostatin receptor, and estrogen receptor tracers, along with quantitative parameters such as SUV, MTV, and TLG. It unifies patient preparation, radiopharmaceutical injection, scanning protocols, and report writing to ensure a consistent quality. PET is indicated for pretreatment staging, efficacy evaluation, recurrence detection, prognostic assessment, and radiotherapy target delineation in patients with major cancers. However, its limitations include false negatives in low-metabolism tumors, tumor heterogeneity, and resolution constraints. Multimodal imaging, combined tracers, and advanced equipment are recommended to improve the accuracy. This guideline promotes standardized and precise PET applications in the whole-course management of tumors in China.

Holistic Integrative OncologyVol. 5(1)
Chongqing University (CN), Guangxi Medical University (CN), Guilin Medical University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Fudan University (CN), Tianjin Medical University Cancer Institute and Hospital (CN), Zhengzhou University (CN), Fudan University Shanghai Cancer Center (CN), Peking University Cancer Hospital (CN), Jiangxi Provincial Cancer Hospital (CN), Zhejiang Cancer Hospital (CN), Shandong Tumor Hospital (CN), Third Affiliated Hospital of Harbin Medical University (CN), Fourth Hospital of Hebei Medical University (CN), Hunan Cancer Hospital (CN), Sichuan Cancer Hospital (CN), First Affiliated Hospital of Xi'an Jiaotong University (CN), Cancer Hospital of Chinese Academy of Medical Sciences (CN), Henan Cancer Hospital (CN), Sun Yat-sen University Cancer Center (CN), Chongqing Cancer Hospital (CN), Tumor Hospital of Guangxi Medical University (CN), Huashan Hospital (CN), Hubei Cancer Hospital (CN), Air Force Medical University (CN)
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Medical Imaging Techniques and Applications
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