Is it appropriate to adjust the treatment of a patient with type 2 diabetes and an HbA1c of 12.8 to metformin 1850 mg and basal-bolus insulin, considering they are already taking metformin 1000 mg and sitagliptin 50 mg every 24 hours, and have a glom

No direct comparative evidence between metformin 1850 mg with basal-bolus insulin and metformin 1000 mg with sitagliptin for managing type 2 diabetes was identified. Clinical guidelines support treatment intensification to include insulin at high HbA1c levels, such as 12.8%.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-10-30
DOI
https://doi.org/10.5281/zenodo.23804811
Primary Topic
Diabetes Treatment and Management
Type
article
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article

Is it appropriate to adjust the treatment of a patient with type 2 diabetes and an HbA1c of 12.8 to metformin 1850 mg and basal-bolus insulin, considering they are already taking metformin 1000 mg and sitagliptin 50 mg every 24 hours, and have a glom

Tripdatabase
Zenodo (CERN European Organization for Nuclear Research)
Diabetes Treatment and Management
article

Is it appropriate to adjust the treatment of a patient with type 2 diabetes and an HbA1c of 12.8 to metformin 1850 mg and basal-bolus insulin, considering they are already taking metformin 1000 mg and sitagliptin 50 mg every 24 hours, and have a glom

Tripdatabase
article en

Abstract

No direct comparative evidence between metformin 1850 mg with basal-bolus insulin and metformin 1000 mg with sitagliptin for managing type 2 diabetes was identified. Clinical guidelines support treatment intensification to include insulin at high HbA1c levels, such as 12.8%.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 11%
Diabetes Treatment and Management
DOIOpen Access PDFOpenAlex
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Is it appropriate to adjust the treatment of a patient with type 2 diabetes and an HbA1c of 12.8 to metformin 1850 mg and basal-bolus insulin, considering they are already taking metformin 1000 mg and sitagliptin 50 mg every 24 hours, and have a glom — Tripdatabase · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS