Aggressive Hepatic AL Amyloidosis Encountering Therapeutic Frailty: Rapid Organ Reversal With Tailored Daratumumab‐Based Therapy and Low‐Dose Corticosteroids in a Patient With Steroid‐Induced Psychosis
ABSTRACT Hepatic AL amyloidosis can cause severe cholestasis independent of marrow tumor burden. In patients with absolute contraindications to high‐dose steroids—such as steroid‐induced psychosis—tailored daratumumab regimens with low‐dose corticosteroids can drive rapid, life‐saving organ reversal. However, intensive antimicrobial vigilance remains mandatory.
Authors
- G. Goteri
- E. Morsia
- Andrea Ranghino (ORCID: https://orcid.org/0000-0002-6976-7539)
- Massimo Offidani (ORCID: https://orcid.org/0000-0003-2749-7347)
- Antonella Poloni (ORCID: https://orcid.org/0000-0002-4221-4125)
- A. Mandolesi
- Sonia Morè (ORCID: https://orcid.org/0009-0007-4398-7860)
- Mauro Valente (ORCID: https://orcid.org/0009-0002-9053-5895)
- R. Ceccarelli (ORCID: https://orcid.org/0009-0002-1196-6479)
Institutions
- Marche Polytechnic University (IT)
- Azienda Ospedaliero Universitaria Ospedali Riuniti (IT)
Publication Details
- Journal
- Clinical Case Reports
- Published
- 2026-10-29
- DOI
- https://doi.org/10.1002/ccr3.73831
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00