QUALITY-BY-DESIGN APPROACH FOR THE DEVELOPMENT AND PERFORMANCE EVALUATION OF A HERBAL THERAPEUTIC TOOTHPASTE

Objective-In the present study an attempt was made to formulate Herbal medicated Toothpaste containing Psidium Guajava Linn (Guava) extract and was evaluated for antimicrobial activity against different microorganisms. Method-The leaves of Psidium Guajava Linn plant was collected and extracted with a suitable solvent. Different toothpastes were formulated by using Design of Experiment. The toothpaste was designed by using Psidium guajava Linn extract, Hydroxy Propyl Methyl Cellulose, sodium carboxy methyl cellulose, sodium saccharide, alum, calcium carbonate, sodium lauryl sulphate, clove oil, peppermint oil, glycerine, polyethylene glycol (PEG -400), methyl paraben, propyl paraben etc. Result-In present study formulated herbal toothpaste was evaluated for its organoleptic and physical properties such as colour, odour, taste, pH, spreadability, viscosity, moisture content, fineness, foamability etc. as per standards specified by Bureau of Indian Standards and compared with commercially marketed herbal toothpaste formulations. The herbal medicated toothpaste showed that the formulation containing Psidium guajava Linn (Guava) extract have better Antibacterial activity. Conclusion-In the present study, the toothpaste was prepared by using various herbal ingredients which possess antibacterial, antiseptic and cooling properties. Formulation of toothpaste with Psidium guajava Linn (Guava) extract was acceptable and might be considered as a desirable herbal medicated toothpaste.