DESENVOLVIMENTO DE VACINAS PARA COVID-19: UMA REVISÃO COM ÊNFASE NAS REAÇÕES ADVERSAS

The study aimed to systematize information and critically contextualize the history and challenges of vaccine development, focusing primarily on serious adverse reactions in light of the COVID-19 pandemic and the ChAdOx1 nCov-19 immunobiological. To this end, an integrative literature review was conducted, outlined by a search for scientific articles and bibliographies across major national and international electronic repositories. The descriptors used for the search were: SARS-CoV-2, COVID-19, history, immunization, vaccines, vaccine development, ChAdOx1 nCov-19, BNT162b2, adverse effects, and thrombosis, as well as their respective English translations. The findings externalize and reinforce that such occurrences do not compromise the efficacy and safety of vaccines; rather, they drive technological refinement, the improvement of surveillance, and a deeper understanding of immune-mediated mechanisms. Consequently, the development of immunizers and new public health strategies are strengthened, contributing to the control and prevention of infectious diseases.