Rapid inter-regional and cross-border dissemination of carbapenemase-producing Klebsiella pneumoniae ST6668, European Union, April 2022 to August 2026
Preliminary analysis of genomic surveillance data from the European Antimicrobial Resistance Gene Surveillance Network detected the spread of the emerging carbapenemase-producing Klebsiella pneumoniae sequence type ST6668 in 19 NUTS-2 regions in Italy (8 regions) and five other European Union (EU) countries (11 regions) in the period April 2022 to August 2026. These findings demonstrate the vulnerability of EU healthcare facilities to the rapid spread of K. pneumoniae high-risk lineages from uncontrolled local outbreaks via national and cross-border patient mobility.
Authors
- Sara Giancristofaro (ORCID: https://orcid.org/0009-0006-4678-2062)
- Giulia Errico (ORCID: https://orcid.org/0000-0001-9151-0652)
- Priyanka Nannapaneni (ORCID: https://orcid.org/0000-0003-2629-4249)
- Anke Kohlenberg (ORCID: https://orcid.org/0009-0001-6322-9844)
- Monica Monaco (ORCID: https://orcid.org/0000-0002-6628-1621)
- Daniela Tălăpan (ORCID: https://orcid.org/0000-0001-5202-8417)
- Alessandra Lo Sciuto
- Dragoş Florea (ORCID: https://orcid.org/0000-0001-7328-6861)
- Lisa-Marie Höfken
- Valentina Libri (ORCID: https://orcid.org/0000-0002-2080-1089)
- Laurent Dortet (ORCID: https://orcid.org/0000-0001-6596-7384)
- Rémy A. Bonnin (ORCID: https://orcid.org/0000-0002-2307-3232)
- Felix Reichert (ORCID: https://orcid.org/0000-0003-3205-3513)
- Olov Svartström (ORCID: https://orcid.org/0000-0003-3100-5325)
- Anette Marie Hammerum (ORCID: https://orcid.org/0000-0001-9471-1601)
- Cristiana Barbati (ORCID: https://orcid.org/0000-0003-4121-5342)
- Marius Linkevičius (ORCID: https://orcid.org/0000-0001-5760-2721)
- Erik Alm (ORCID: https://orcid.org/0000-0002-2903-607X)
- Antoni P. A. Hendrickx (ORCID: https://orcid.org/0000-0003-4431-9323)
- Manuela Marra (ORCID: https://orcid.org/0000-0001-9710-118X)
- Louise Roer (ORCID: https://orcid.org/0000-0001-6892-913X)
- María Del Grosso (ORCID: https://orcid.org/0000-0002-2663-9764)
- the Italian CRE25 survey working group for Klebsiella pneumoniae ST6668
Institutions
- Statens Serum Institut (DK)
- Inserm (FR)
- Carol Davila University of Medicine and Pharmacy (RO)
- Robert Koch Institute (DE)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Istituto Superiore di Sanità (IT)
- Assistance Publique – Hôpitaux de Paris (FR)
- National Institute for Public Health and the Environment (NL)
- CEA Paris-Saclay (FR)
- Bicêtre Hospital (FR)
- European Centre for Disease Prevention and Control (SE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Eurosurveillance
- Published
- 2026-10-29
- DOI
- https://doi.org/10.2807/1560-7917.es.2026.31.43.2600861
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00