Implementation of a Guideline for Short-Course Amikacin to Treat Multidrug-Resistant Urinary Tract Infections in Children
We implemented an institutional guideline to facilitate extended-interval amikacin dosing for multidrug-resistant urinary tract infections. Amikacin was recommended as a single dose for uncomplicated cystitis and as three once-daily doses for pyelonephritis. After policy implementation, use of extended-interval amikacin became routine, and approximately one-quarter of amikacin-treated patients avoided admission.
Authors
- Daniel Pak (ORCID: https://orcid.org/0009-0005-5743-3741)
- Scott J. Weissman (ORCID: https://orcid.org/0000-0002-3755-4010)
- Matthew P. Kronman (ORCID: https://orcid.org/0000-0002-1856-6841)
- Victoria Konold (ORCID: https://orcid.org/0000-0002-7026-1930)
- Indi Trehan (ORCID: https://orcid.org/0000-0002-3364-6858)
- Adam W. Brothers (ORCID: https://orcid.org/0009-0003-5973-4965)
- Derry R. McDonald (ORCID: https://orcid.org/0000-0001-6215-7765)
Institutions
- Seattle Children's Hospital (US)
- University of Washington (US)
Publication Details
- Journal
- Journal of the Pediatric Infectious Diseases Society
- Published
- 2026-10-30
- DOI
- https://doi.org/10.1093/jpids/piag113
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00