Xylarimides A and B, Unusual 21 Membered Cyclic Depsipeptides Featuring a 3-Furan-2-Hydroxypropionic Acid Unit, Target ATG7 to Induce Lethal Autophagy in Renal Cancer Cells
Abstract Xylarimides A and B, two novel 21-membered cyclic depsipeptides, were isolated from the fungus Xylaria striata. Both compounds feature a previously undescribed 3-furan-2-hydroxypropionic acid moiety. Xylarimide A potently inhibits the proliferation of the renal cancer cell lines and the growth of 786-O xenografts in a mouse model. Mechanistically, xylarimide A activates autophagic flux while suppressing AKT-mTOR signaling by directly targeting the core protein ATG7, inducing lethal autophagy.
Authors
- Gu He (ORCID: https://orcid.org/0000-0002-1536-8882)
- Guo‐You Li (ORCID: https://orcid.org/0000-0001-9690-4044)
- Fei Wang (ORCID: https://orcid.org/0000-0002-2513-502X)
- 睿英 席
- Chuanwen Lei
- Xiaohong Yuan
- Xiang Li
Institutions
- Southwest University of Science and Technology (CN)
- Sichuan University (CN)
- Chengdu Institute of Biology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-10-30
- DOI
- https://doi.org/10.1021/acs.orglett.6c04183
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chengdu Institute of Biology