Matrix-derived hypoallergenicity: potential roles of Beta vulgaris polyphenols and betalamic acid in PR-10 allergen modulation

Cold-pressed apple, carrot, and celery juices retain native PR-10 allergens associated with Pollen-Food Allergy Syndrome, whereas thermal processing can alter allergen recognition while compromising heat-sensitive nutrients and sensory quality. We propose matrix-derived hypoallergenicity, a framework in which food-matrix chemistry may regulate allergen accessibility. Using beetroot ( Beta vulgaris ) as a model matrix, we examine two chemically plausible pathways, polyphenol-derived quinone modification and betalamic-acid-mediated carbonyl chemistry. Neither pathway has been validated in authentic juice systems. This perspective, therefore, defines a testable framework for modulating allergen behavior while preserving nutritional and sensory quality.