Metabolic licensing of innate immune memory
NAD + is revealed to be a metabolic signal that preserves an epigenetic mark central to trained immunity by inhibiting the histone demethylase KDM5a (see related Research Article by Jin et al. ).
Authors
- Musa M. Mhlanga (ORCID: https://orcid.org/0000-0003-1381-3409)
- Andrew A. Pieper (ORCID: https://orcid.org/0000-0001-6299-6577)
Institutions
- Radboud University Nijmegen (NL)
- University Hospitals of Cleveland (US)
- Radboud University Medical Center (NL)
- University Hospitals Cleveland Medical Center (US)
- Radboud Institute for Molecular Life Sciences (NL)
- Louis Stokes Cleveland VA Medical Center (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Science Immunology
- Published
- 2026-10-30
- DOI
- https://doi.org/10.1126/sciimmunol.aek9099
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation
- Paul G. Allen Family Foundation
- Chan Zuckerberg Initiative