Correctness and Completeness of a Multimodal Large Language Model in the Diagnosis and Treatment Recommendations for Proximal Femoral Fractures

Background and Objectives: To compare the diagnostic and therapeutic performance of a multimodal large language model (GPT) with that of two human evaluators in proximal femoral fracture (PFF) assessment, focusing on correctness and completeness. Materials and Methods: A consecutive series of 250 PFFs was reconstructed into standardized clinical scenarios including radiographs and structured clinical data. Each case was independently evaluated by a trauma fellow, a second-year orthopaedic resident, and GPT. Responses were scored for diagnostic and treatment correctness and completeness. Severe treatment errors were predefined as category-changing mismatches, failure to recognize an existing implant, or incorrect laterality. Results: Fully correct diagnoses were achieved in 97.2% of cases by the fellow, 44.8% by the resident, and 14.0% by GPT (p < 0.001). GPT showed lower odds of correct diagnosis compared with the resident (matched OR 0.23, 95% CI 0.14–0.37) and fellow (OR 0.005, 95% CI 0.0001–0.03), with clustering of errors in extracapsular fractures. Diagnostic completeness also differed significantly (p < 0.001), with GPT providing fully complete assessments in 60.4% of the cases (151/250). Fully correct treatment recommendations were provided in 98.8%, 81.2%, and 36.4% of cases, respectively (p < 0.001). Severe treatment errors occurred in 58.8% of GPT outputs versus 2.0% and 0% for the resident and fellow (OR vs. resident 36.5, 95% CI 13.95–135.75). Although treatment completeness was high (93.2%), 58.8% (147/250) of GPT responses were complete but incorrect. Conclusions: GPT demonstrated substantial limitations in both diagnostic and therapeutic reasoning for PFF, with frequent pattern-dependent errors and a high rate of clinically consequential treatment mismatches.

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Journal
Medicina
Published
2026-10-30
DOI
https://doi.org/10.3390/medicina62112106
Primary Topic
Artificial Intelligence in Healthcare and Education
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article
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article

Correctness and Completeness of a Multimodal Large Language Model in the Diagnosis and Treatment Recommendations for Proximal Femoral Fractures

Marco Maestri, Francesco Traina, Serena Santoro, Francesco Castagnini et al.
5 links
Medicina
Artificial Intelligence in Healthcare and Education
article

Correctness and Completeness of a Multimodal Large Language Model in the Diagnosis and Treatment Recommendations for Proximal Femoral Fractures

Marco Maestri, Francesco Traina, Serena Santoro, Francesco Castagnini, Nicola Valerio Capitaneo, Rosalinda Ventimiglia, Giovan Battista Scimeca
article en

Abstract

Background and Objectives: To compare the diagnostic and therapeutic performance of a multimodal large language model (GPT) with that of two human evaluators in proximal femoral fracture (PFF) assessment, focusing on correctness and completeness. Materials and Methods: A consecutive series of 250 PFFs was reconstructed into standardized clinical scenarios including radiographs and structured clinical data. Each case was independently evaluated by a trauma fellow, a second-year orthopaedic resident, and GPT. Responses were scored for diagnostic and treatment correctness and completeness. Severe treatment errors were predefined as category-changing mismatches, failure to recognize an existing implant, or incorrect laterality. Results: Fully correct diagnoses were achieved in 97.2% of cases by the fellow, 44.8% by the resident, and 14.0% by GPT (p < 0.001). GPT showed lower odds of correct diagnosis compared with the resident (matched OR 0.23, 95% CI 0.14–0.37) and fellow (OR 0.005, 95% CI 0.0001–0.03), with clustering of errors in extracapsular fractures. Diagnostic completeness also differed significantly (p < 0.001), with GPT providing fully complete assessments in 60.4% of the cases (151/250). Fully correct treatment recommendations were provided in 98.8%, 81.2%, and 36.4% of cases, respectively (p < 0.001). Severe treatment errors occurred in 58.8% of GPT outputs versus 2.0% and 0% for the resident and fellow (OR vs. resident 36.5, 95% CI 13.95–135.75). Although treatment completeness was high (93.2%), 58.8% (147/250) of GPT responses were complete but incorrect. Conclusions: GPT demonstrated substantial limitations in both diagnostic and therapeutic reasoning for PFF, with frequent pattern-dependent errors and a high rate of clinically consequential treatment mismatches.

MedicinaVol. 62(11)
Azienda USL di Bologna (IT), Istituto Ortopedico Rizzoli (IT), University of Bologna (IT)
Good health and well-being
Openalex Percentile: Top 20%
Artificial Intelligence in Healthcare and Education
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