SYNTHESIS AND BENZOXAZOLE DERIVATIVES POTENTIAL ACTIVITY OF ANTI -CANCER AGENT

This work is one of our efforts to discover potent anticancer agents. We modified the most promising derivative of our previous work concerned with the development of inhibitor candidates. Thirteen new compounds based on benzoxazole moiety weresynthesized andevaluated against three human cancer cell linesBenzoxazole and its derivatives of heterocylic compounds possessing nitrogen, oxygen and oxazole moieties which are the important structures of several pharmacologically active compounds. Benzoxazole analogues shows vigorous effects. According to the previous research, benzoxazole is produced by reflexing CS2 and O-aminophenol. These derivatives of benzoxazole produce Good anti- breast cancer activity. This review includes the synthesis and the anticancer activity of benzoxazole and its analogues. This study can help the future chemists focusing on the synthesis of drugs related to anticancer activity. Benzoxazole are having key role in the medicinal chemistry due to their wide spectrum of pharmacological activity. The biological activities shown by benzoxazole and its analogues are mainly antifungal, antihistaminic, anti-cancer, antiinflammatory, anti-viral, anti-bacterial. Benzoxazoles gained importance because of use in intermediates for the preparation of new drugs.