Macrophages iron out cancer cells’ vulnerability
Surviving despite accumulating toxic metabolites inside the cell is a defining feature of cancer evolution. In the current issue of Cell Reports , Eric Cheung and coworkers identify a mechanism that enables the survival of malignant pancreatic ductal adenocarcinoma (PDAC) cells through the sequestration of reactive iron. 1 1. Cheung, E. ∙ Wu, M.-H. ∙ Cheng, W.-C. ... Macrophage-Induced Ferritin Expression Protects Pancreatic Cancer Cells from Ferroptosis Cell Rep. 2026; 45 Full Text Full Text (PDF) Scopus (0) Google Scholar
Authors
- Alessandro Carrer (ORCID: https://orcid.org/0000-0002-9300-6879)
Institutions
- University of Padua (IT)
- Veneto Institute of Molecular Medicine (IT)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-10-30
- DOI
- https://doi.org/10.1016/j.celrep.2026.118143
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00