Reproductive Defects in glis3 Mutant Zebrafish

When the transcription factor glis3 is no longer present in zebrafish, a variety of issues present, including polycystic kidney disease, neonatal diabetes, and reproductive defects. The reproductive defects could be due to a variety of factors, including dysfunction of the thyroid and pituitary gland. This presentation seeks to further characterize the role of glis3 in the development and function of the reproductive system.