Condensate dynamics drive adaptive METTL3 1 inhibitor resistance
The RNA methyltransferase METTL3 installs N6-methyladenosine (m6A) on mRNA1,2 and is an emerging therapeutic target in cancer3-9. Yet, how cells fundamentally and dynamically respond to disruption of the m6A RNA methylation machinery and what drives resistance to the catalytic inhibition of METTL310,11 remains unknown. Using genome wide CRISPR sensitization and resistance screens, we identify the nuclear m6A
Authors
- Konstantinos Tzelepis (ORCID: https://orcid.org/0000-0002-4865-7648)
- George Vassiliou
- Brian Huntly
- Alcolea
Publication Details
- Journal
- Apollo (University of Cambridge)
- Published
- 2026-10-29
- DOI
- https://doi.org/10.17863/cam.136338
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust