Pericytes and endothelial cells act as mutual, yet incomplete safeguard to sustain lung microvascular networks in pulmonary arterial hypertension
Extract Pulmonary arterial hypertension (PAH) results from extensive remodeling along the length of the arterial-to-microvascular vessel tree. Prior studies focused primarily on cellular signals driving remodeling of pulmonary arteri(ol)es in PAH. Accordingly, approved therapies target arterial vasodilation and reverse remodeling [1]. In parallel, PAH is characterized by loss (rarefaction) of pulmonary microvessels and capillaries the critical role of which is highlighted by a close correlation of vascular volume with disease severity [2].
Authors
- Q. Zhang (ORCID: https://orcid.org/0009-0004-5758-6345)
- Luisa Tenkhoff
- Wolfgang Michael Kuebler (ORCID: https://orcid.org/0000-0003-4100-2961)
- Soheila Zeinali (ORCID: https://orcid.org/0000-0003-3896-596X)
- Vinicio de Jesús Pérez (ORCID: https://orcid.org/0000-0001-5532-8247)
- Lasti Erfinanda (ORCID: https://orcid.org/0000-0003-4974-154X)
- Olivier T. Guenat (ORCID: https://orcid.org/0000-0003-1103-9712)
- J. J. P. v. d. Kamp (ORCID: https://orcid.org/0009-0009-4088-3796)
- Elisabeth Weber
- Paul Neumann
Institutions
- University of Bern (CH)
- Stanford Medicine (US)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Stanford University (US)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2026-10-29
- DOI
- https://doi.org/10.1183/23120541.01843-2025
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Deutsche Forschungsgemeinschaft
- Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.
- National Institutes of Health