Dopamine turns mitochondrial stress into inflammation
Daniali et al. show that dopamine drives mitochondrial stress, mtDNA release, and cGAS-STING-dependent IL-6 production in human macrophages. These findings suggest a mechanism linking dopaminergic signaling to mtDNA damage signatures increasingly detected in blood from patients with Parkinson's disease.
Authors
- Rodrigo Pacheco (ORCID: https://orcid.org/0000-0001-8057-9806)
Institutions
- Universidad San Sebastián (CL)
- Fundación Ciencia and Vida (CL)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-10-29
- DOI
- https://doi.org/10.1016/j.celrep.2026.118138
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00