The Blind Spot of GeneXpert MTB / RIF : Isoniazid‐Resistant, Rifampicin‐Susceptible Tuberculosis Detected on Phenotypic Drug Susceptibility Testing
ABSTRACT GeneXpert MTB/RIF detects only rifampicin resistance. A 19‐year‐old man with cough and haemoptysis had rifampicin‐susceptible tuberculosis on bronchoalveolar lavage Xpert. Phenotypic drug susceptibility testing later revealed isolated isoniazid resistance, and isoniazid was replaced with levofloxacin. Additional susceptibility testing is essential to detect isoniazid‐resistant, rifampicin‐susceptible tuberculosis.
Authors
- Rabbia Abbas
- Ali Gohar (ORCID: https://orcid.org/0000-0002-7357-1977)
- Muhammad Husnain Ahmad (ORCID: https://orcid.org/0009-0006-5248-0749)
- Hafiz Muhammad Faisal Nadeem (ORCID: https://orcid.org/0009-0004-8364-4027)
- Taqdees Noor (ORCID: https://orcid.org/0009-0002-6397-688X)
- Muhammad Faisal Jakhar
Institutions
- Lahore General Hospital (PK)
- S. Tentishev Asian Medical Institute (KG)
Publication Details
- Journal
- Respirology Case Reports
- Published
- 2026-10-28
- DOI
- https://doi.org/10.1002/rcr2.70799
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00